Cellulite injections

Cellulite injections? Up to 90% of adult women have cellulite, typically on the abdomen, buttocks, and thighs. However, there's a new kid on the block, and it's called QWO.

It's the first FDA-approved injectable that's used for cellulite treatment. It's actually approved for women for the buttock region. QWO injections help break down old collagen particles and make new ones where cellulite dimples are.

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What is QWO? 

It comes in a vial. It's a simple injectable to treat moderate to severe cellulite, and it's provided by an experienced healthcare provider. These injections use collagenase clostridium histolyticum to break down the fibrous bands that connect the skin to muscle and trap fat in pockets, creating cellulite.

They do it as a series of three to four cellulite treatments to destroy those fibrous septae that cause skin dimpling. QWO has been authorized by the FDA to be given three times in 21-day intervals.

How do cellulite injections work?

Doctor injecting on cellulite

I think that's really important to know well. QWO is collagenase which is an enzyme that breaks down collagen. This collagenase is so important to cellulite because we build fibrous septae or solid collagen bands within our fat tissue.

You know fat, and its structure in men versus women is very different, and so within fat underneath the surface of our skin, we've got these little areas of connective tissue bands formed from collagen.

So it makes sense to enzymatically snip these guys to release the fibrous bands and allow the skin's smooth texture to be improved rather than having discrete dimples.

When injected, Qwo enzymatically releases the fibrous connective tissue responsible for drawing down the skin and creating dimpling in cellulite.

These fibrous bands tether down dimpled skin, so QWO is collagenase, an enzyme that breaks down collagen.

It's essential to break down these fibrous septae or this little tissue, almost parachutes. These fibrous septae are like the tines of an umbrella, pulling down the skin's surface and causing unsightly irregularities.

Side effects

Its simple and easy side effects are pretty minimal almost everybody gets:

  • Some bruising, especially with the first treatment.
  • A little bit of swelling.
  • Some slight discomfort

However, side effects are pretty minimal downtime. It was FDA approved with buttocks in uh July of 2020.

How does the surgeon do in a cellulite reduction session?

Your surgeon begins by drawing dots on the cellulite dimples on your bottom that will be injected. Next, the surgeon injects QWO with a tiny needle, which does not need to be made too deeply because there are more fat and fewer nerves in the buttocks than in other parts of the body.

Patients tell these injections to hurt less than Botox or dermal fillers due to this reason. Topical numbing cream isn't necessary for delivery either as it’s non-invasive, so sessions take just 10-20 minutes or so overall.


84% of patients from the Qwo clinical trials showed symptoms of bruising. Nodules may appear, but they are usually removed in seven to eight days. Bruising is a deepening problem resulting from the injection.

With each subsequent round, an overall decrease in incidents, severity duration happens. However, should a person suffer an extreme hypersensitivity reaction, they should seek medical attention immediately.

Do not schedule injectable treatments close to events where you might need to wear something more revealing like a swimsuit. If a person experiences symptoms of hyperactivity after treatment subsequently, they have to seek medical attention.

Other cellulite treatments


Lanluma is the new injectable collagen stimulator to remodel and improve your booty. It's the injection that helps you get a smoother skin surface with more volume in less time! To smooth, reshape and sculpt your bottom.

Lanluma is a medically-approved injectable treatment that uses polylactic acid to improve the quality of one's skin. It reduces wrinkles, treats sagging parts of the body such as buttocks or arms and hands, rejuvenates faces/v necks & decolletés, and smoothes out any contours in your figure.

Lanluma is an injection-based on PLLA (polylactic acid), which acts as an activator for natural collagen production so it can aesthetically enhance areas like facial features, breasts, hips, thighs, etc. while also improving their circulation by increasing blood flow Lanluma smooths shapes, sculpts, enhances curves and contouring rejuvenating aging flaccidity treating inner face legs with


By using a combination of radiofrequency and shockwaves, the EMTONE treatment reshapes subcutaneous fat cells. As a result, the skin also tightens to improve sagging skin from cellulite or other body tissues such as flabbiness in arms.

It is suitable for all common problem areas: arms, abdomen, hips/thighs, buttocks, and even backside! All degrees of cellulite can be treated on any type or kind of skin along with various kinds of bodies shapes and sizes.


Cellfina is the first FDA-approved minimally invasive treatment for treating cellulite that prevents cellulite appearance for at least two years. To smooth out dimples, the therapy cuts some of the above-described fibrous tissue with tiny needle devices.

You'll also have temporary bruising, but you'll see results within about a week, advises Joel Schlessinger, MD dermatologist in Omaha, Nebraska.

If you've got special spots you wish to treat, this may be suitable for you, Chwalek says. This product has been specifically designed for small discolorations on the skin.


Velashape combines infrared light with radiofrequency and the power of massage with suction to promote lymphatic drainage. It is FDA-approved and considered a non-invasive therapy. Results appear after the first four treatments.

It's cheaper than Cellfina, but it requires returning almost every three months to realize an effective improvement. This technique will be perfect for those with slight dimpling or who want a slimmer silhouette in the treated areas.


The FDA approved Thermage CPT. It is a radiofrequency treatment that uses your natural collagen to treat cellulite and combat skin laxity. In addition, the esthetician can use it on the abdomen, thighs, or buttocks for enhanced tone & texture, so you feel more confident in your clothes!

Thermage is a non-invasive skin tightening treatment that uses heat and cold to tighten the deep structure of your skin. The immediate results are smoother, tighter-looking skin with an improvement in fine lines within one month after you've had it done. It's safe for all types of complexions and colors as well!


A new surgical technique known as Vaser or lipo Vaser can help you sculpt your body and define muscles in the treatment area. This innovative procedure is performed using a small cannula inserted subcutaneously, which dilutes the fat with ultrasound.

The surgery eliminates stubborn cellulite but preserves the skin and other tissues. This is because it's done through an ultrasound that liquefies only specific areas of fatty tissue without affecting anything else in the area where treatment takes place.

What is the difference between invasive and non-invasive treatments?

Non-invasive procedures do not penetrate the skin or mucous membranes, so there is no surgery involved. Minimally invasive procedures have needles that can enter into the skin and subcutaneous tissue but without any cuts to its surface. This means less blood loss occurs during such an operation on human body parts. Invasive procedures involve surgical methods and include operations inside the skin.

Examples of non-invasive treatments

QWO is a minimally invasive procedure to treat moderate or severe cellulite that has been cleared by US FDA in June 2020 to be performed as an infra-dermal injection under the skin on specific body regions, including the buttock. After administration, particles diffuse through interstitial spaces within subcutaneous tissue, leading to collagen fibrils in that area.

How is QWO different from other treatments? You have many options available for the cellulite treatment today, but your dermatologist or plastic surgeon can administer not all. Here's why: QWO provides a safe and effective option to those who don't want surgery or another invasive procedure.

Examples of invasive treatments

Cosmetic surgery like liposuctions is an invasive procedure. Anesthesia is required, and this poses a risk to your life and can have side effects. Microdermabrasion, laser resurfacing, or radiofrequency treatment options are available in some clinics may be effective in treating cellulite and tightening the skin. But again, every treatment has risks and side effects that you should carefully weigh when considering any procedure.


If you want to know more about cellulite injections, be sure to read our blog post. We've given a lot of information that will help you decide if this is an option for your body type or not.

For example, did you know there are two types of treatments, non-invasive and invasive? You'll also learn how many treatments it takes to see results. So be sure to get all the facts before making any decisions! (Trusted Sources 1*, 2*, 3*, 4*)

Medically reviewed and approved by Nataniel Josue M D.